Prepare to be amazed by these incredible dolphins! Not only are they intelligent and captivating creatures, but they have also been trained to wear cameras. This allows marine biologists to get a firsthand look at their fascinating behaviors, such as hunting techniques and their efforts to rescue endangered vaquita porpoises. It’s clear that we have a lot to learn from our marine friends and a responsibility to help them thrive.
Enter Dr. Stephanie Venn-Watson, a veterinary epidemiologist with a background at the World Health Organization. Venn-Watson and her team noticed a curious pattern among Navy dolphins – some were developing age-related conditions while others were not. For instance, they discovered that about one in three dolphins developed fatty liver disease, which interestingly mirrors the ratio in humans.
Intrigued by these findings, Venn-Watson and her team embarked on a comprehensive investigation. They conducted a metabolomic study, analyzing thousands of molecules in the dolphins’ bodies to understand their functions. This research led them to identify 100 different molecules that predicted the healthiest dolphins, with C15:0 emerging as the top contender.
So, what exactly is C15:0?
C15:0, also known as pentadecanoic acid, is an odd-chain fatty acid. Fatty acids play a crucial role in every cell of the body, particularly in the formation of lipid bilayer membranes. These membranes act as protective barriers around cells, facilitating essential functions and allowing for the exchange of vital substances. And guess what? Fatty acids are a key component of these membranes!
Now, here’s the interesting part – most fatty acids are obtained through diet, and C15:0 is no exception. In the wild, dolphins naturally acquire this fatty acid from the skin and heads of fish. Yum!
When the researchers provided dolphins with a diet higher in fish-based C15:0, they observed significant improvements in the health of those aging less gracefully.
But what about humans? Is C15:0 important for us too?
Further investigations revealed that humans may also suffer from C15:0 deficiency. Numerous studies have shown that lower C15:0 dietary intake and blood concentrations are associated with higher mortality rates and poorer physiological states.
Now, before you start munching on fish skin and heads, let’s explore other sources of this beneficial fatty acid for humans. Whole-fat cow’s milk and butter are rich in C15:0, providing a more palatable option for most people.
Unfortunately, our modern dietary habits have shifted away from these sources. In the late 1970s, there was a push to reduce saturated fat intake, which coincided with an alarming increase in conditions like type 2 diabetes, obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD) in the US.
What does the research say about C15:0?
Venn-Watson’s team conducted various studies to demonstrate the benefits of C15:0 for humans. In fact, it’s the first essential fatty acid discovered in 90 years! Their research showed that C15:0 has anti-inflammatory and antifibrotic properties, effectively halts the progression of severe liver fibrosis, and protects cell membranes from damage.
And they’re not alone in their findings. Over 50 peer-reviewed papers from different institutions support the value of C15:0. Studies have linked higher C15:0 levels to lower liver fat in children, a reduced risk of severe NAFLD, and highlighted its importance in dairy fat for models of NAFLD/NASH.
Excitingly, an ongoing clinical trial is currently investigating C15:0 supplementation in young adults at risk of metabolic syndrome and fatty liver disease. Results are expected early next year.
Dr. Stephanie Venn-Watson, Co-founder and CEO of Seraphina Therapeutics, believes that replenishing our C15:0 levels could be a game-changer for global health. She emphasizes the potential to restore long-term health and extend longevity for all.
Aside from its health benefits, C15:0 also improves cellular stability by a staggering 80% by strengthening cell membranes.
Why do humans need supplements instead of relying solely on diet?
Unfortunately, it’s not as simple as eating our way to sufficient C15:0 levels. Plant-based milk products lack this fatty acid entirely, and the amount in whole-fat cow’s milk depends on the cows’ diet. Additionally, C15:0 levels naturally decline with age, increasing the risk of deficiencies as we get older.
That’s where supplements come in. Venn-Watson and her team have developed Fatty15, a supplement containing pure C15:0.
